WHY DOES THIS PLATFORM EXIST?

Individual risk and population harm associated with smoking cigarettes may potentially be reduced by offering reduced-risk alternative products to smokers who would otherwise continue smoking cigarettes.
INTERVALS was designed to allow all relevant stakeholders to share and explore toxicity assessment data produced in relation to alternative products to cigarettes.

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Join the INTERVALS community

It is time for the community to come together and to build the science around tobacco harm reduction, including the development of testing methods that may be used in the wider context of inhalation toxicology.

If you have relevant results, data, or protocols to share, please register and upload them to the platform and you will be able to get the community's feedback as well as contribute to this crucial undertaking.

The platform is under continuous development. Don't hesitate to share your feedback with us!

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HOW YOU CAN CONTRIBUTE:

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RESOURCES

  • AeroSolved is a Computational Fluid Dynamics code, based on the OpenFOAM software package, for simulation of the generation, transport, evolution, and deposition of multispecies aerosol mixtures. The AeroSolved website includes tutorial cases, documentation, and links to the code hosted on GitHub.

  • The Causal Biological Networks (CBN) database is composed of multiple versions of over 120 modular, manually curated, BEL-scripted biological network models describing lung and cardiovascular biology and supported by over 80,000 unique pieces of evidence from the scientific literature.

  • sbv IMPROVER is a crowdsourcing initiative that aims to encourage innovation and evaluation of scientific methods in an industrial setting. By 2020, more than 850 experts from more than 500 institutions based in 65 countries had been part of the 11 sbv IMPROVER challenges and datathons. This resulted in 16 scientific publications and more than 20 collaborations between experts, institutions, and PMI.

  • BioDIVE is a free and versatile platform for applications that enable analysis of large datasets, including gene expression and high-content screening data, to extract relevant biological insights. 2 applications are already available in BioDIVE: CBN Score and GladiaTOX. CBN Score allows users to upload differential gene expression data, process that data through the causal network models, and then download interpretable and hierarchical results that quantify the effects of exposure. GladiaTOX is an all-in-one solution for the analysis of high-content screening (HCS) data.

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